Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Atg1
Flybase description The gene Autophagy-specific gene 1 is referred to in FlyBase by the symbol Dmel\Atg1 (CG10967, FBgn0260945).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.9019 1.1724 -1.258493 -0.4986 -2.497062 -1.9034 -1.71668 -1.956026
    Affimetrix absolute value 7.49 7.845 7.858 8.192 7.517 7.696 7.806 7.31
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: kinesin binding; protein kinase activity.
There is experimental evidence that it is involved in the biological process: regulation of synaptic transmission; regulation of cell growth; nurse cell apoptosis; larval midgut histolysis; synaptic growth at neuromuscular junction; negative regulation of TOR signaling cascade; regulation of autophagy; autophagy; axon cargo transport; synapse organization.
45 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; organ system subdivision; multicellular structure; portion of tissue; anatomical structure; adult; embryonic/larval hemocoel; cytoplasmic part; embryonic/larval fat body; synapse; external compound sense organ.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase Unc-51; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, C-terminal; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.