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|Flybase description||The gene Autophagy-specific gene 1 is referred to in FlyBase by the symbol Dmel\Atg1 (CG10967, FBgn0260945).|
|Expression data along the gut||
|Intestinal gene expression in different physiological conditions||
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
|Gene details (from Flybase)|| It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: kinesin binding; protein kinase activity.
There is experimental evidence that it is involved in the biological process: regulation of synaptic transmission; regulation of cell growth; nurse cell apoptosis; larval midgut histolysis; synaptic growth at neuromuscular junction; negative regulation of TOR signaling cascade; regulation of autophagy; autophagy; axon cargo transport; synapse organization.
45 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; organ system subdivision; multicellular structure; portion of tissue; anatomical structure; adult; embryonic/larval hemocoel; cytoplasmic part; embryonic/larval fat body; synapse; external compound sense organ.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase Unc-51; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, C-terminal; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages.