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| Gene name | Abl | ||||||||||||||||||||||||||||||||||||
| Flybase description | The gene Abl tyrosine kinase is referred to in FlyBase by the symbol Dmel\Abl (CG4032, FBgn0000017). | ||||||||||||||||||||||||||||||||||||
| Expression data along the gut |
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| Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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| Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein tyrosine kinase activity; protein binding. There is experimental evidence that it is involved in the biological process: negative regulation of synaptic growth at neuromuscular junction; regulation of cell shape; central nervous system development; peptidyl-tyrosine phosphorylation; ventral furrow formation; dorsal closure; regulation of protein stability; cytoplasmic transport, nurse cell to oocyte; axon guidance; regulation of protein localization. 46 alleles are reported. The phenotypes of these alleles are annotated with 24 unique terms, many of which group under: organ system subdivision; multi-cell-component structure; commissure; external compound sense organ; presumptive embryonic/larval nervous system; peripheral nervous system; nervous system; extended germ band embryo; synaptic neuropil subdomain; embryonic/larval neuron; female germline cyst; antennal segment; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: F-actin binding; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SH2 motif; Serine-threonine/tyrosine-protein kinase; Src homology-3 domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in adult female stages. . |
