Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name cos
Flybase description The gene costa is referred to in FlyBase by the symbol Dmel\cos (CG1708, FBgn0000352).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -7.7621 -3.8804 -5.967587 -8.1214 -9.798239 -9.9268 -9.67529 -9.278599
    Affimetrix absolute value 5.453 5.68 5.603 5.385 5.505 5.264 5.34 5.042
    Affymetric present call in "x" number of chips 2 3 3 3 2 3 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: smoothened binding; microtubule binding; protein binding; protein kinase binding; transcription factor binding.
There is experimental evidence that it is involved in the biological process: smoothened signaling pathway; regulation of protein stability; negative regulation of sequence-specific DNA binding transcription factor activity; imaginal disc-derived wing morphogenesis; cytoplasmic sequestering of transcription factor; negative regulation of transcription factor import into nucleus; positive regulation of hh target transcription factor activity.
89 alleles are reported.
The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system subdivision; adult segment; organ system; adult mesothoracic segment; thoracic segment; imaginal precursor; dorsal thoracic disc; vagina; vulva; larval thorax; epiproct; non-connected developing system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Kinesin, motor domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, in adult female stages.
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