Flygut: an atlas of the Drosophila adult midgut

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Gene name dnc
Flybase description The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.6878 -2.8294 -4.71633 -5.6491 -9.723132 -5.4032 -8.56801 -6.800195
    Affimetrix absolute value 5.922 6.135 5.983 5.891 5.541 6.13 5.458 5.545
    Affymetric present call in "x" number of chips 3 1 3 3 3 3 1 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: 3',5'-cyclic-AMP phosphodiesterase activity.
There is experimental evidence that it is involved in the biological process: synaptic transmission; conditioned taste aversion; short-term memory; learning; axon extension; lateral inhibition.
72 alleles are reported.
The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: organ system subdivision; organ system; embryonic/larval neuron; nervous system; synapse; peripheral nervous system; female germline cyst; egg; synaptic neuropil subdomain; postsynaptic membrane.
It has 12 annotated transcripts and 12 annotated polypeptides.
Protein features are: 3'5'-cyclic nucleotide phosphodiesterase; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 3'5'-cyclic nucleotide phosphodiesterase, conserved site; Metal-dependent phosphohydrolase, HD domain; Twin-arginine translocation pathway, signal sequence.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression.
Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
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