Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name EcR
Flybase description The gene Ecdysone receptor is referred to in FlyBase by the symbol Dmel\EcR (CG1765, FBgn0000546).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -19.4778 -12.8471 -24.233088 -27.0832 -42.36822 -30.5226 -21.89187 -29.899757
    Affimetrix absolute value 4.129 3.958 3.585 3.653 3.365 3.63 4.135 3.371
    Affymetric present call in "x" number of chips 3 3 1 3 1 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: ecdysteroid hormone receptor activity; protein binding; protein heterodimerization activity; repressing transcription factor binding.
There is experimental evidence for 40 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular process involved in reproduction; multicellular organismal reproductive process; organ development; cellular component organization or biogenesis; embryonic development via the syncytial blastoderm; central nervous system development; post-embryonic organ morphogenesis; determination of adult lifespan; neuron maturation; locomotory behavior; catabolic process; response to cocaine; ecdysis, chitin-based cuticle; prepupal development; memory.
140 alleles are reported.
The phenotypes of these alleles are annotated with 58 unique terms, many of which group under: organ system; organ system subdivision; adult segment; cuticle; imaginal precursor; cephalopharyngeal skeleton; female germline cyst; portion of tissue; egg; extended germ band embryo; cytoplasmic part; spiracle; external compound sense organ; gland.
It has 6 annotated transcripts and 6 annotated polypeptides.
Protein features are: Ecdysteroid receptor; Nuclear hormone receptor, ligand-binding; Nuclear hormone receptor, ligand-binding, core; Steroid hormone receptor; Zinc finger, NHR/GATA-type; Zinc finger, nuclear hormone receptor-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 06-18 hour embryonic stages, during late larval stages, during early pupal stages.
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