Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name en
Flybase description The gene engrailed is referred to in FlyBase by the symbol Dmel\en (CG9015, FBgn0000577).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -45.1035 -29.5475 -49.62235 -51.6839 -58.613155 -59.9077 -57.56082 -38.235751
    Affimetrix absolute value 2.948 2.754 2.558 2.702 2.89 2.668 2.711 2.983
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity.
There is experimental evidence that it is involved in the biological process: anterior commissure morphogenesis; neuroblast fate determination; axon guidance; spiracle morphogenesis, open tracheal system; gonad development; ventral midline development; genital disc development; genital disc anterior/posterior pattern formation.
184 alleles are reported.
The phenotypes of these alleles are annotated with 91 unique terms, many of which group under: organ system subdivision; adult segment; abdominal ventral denticle belt; adult mesothoracic segment; multi-cell-component structure; organ system; presumptive embryonic/larval nervous system; embryonic/larval neuron; antennal segment; nervous system.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Helix-turn-helix motif, lambda-like repressor; Homeobox; Homeobox engrailed; Homeobox engrailed, C-terminal; Homeobox engrailed-type, conserved site; Homeobox, conserved site; Homeobox, eukaryotic; Homeodomain-like; Homeodomain-related.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.
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