Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name E(spl)
Flybase description The gene Enhancer of split is referred to in FlyBase by the symbol Dmel\E(spl) (CG8365, FBgn0000591).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -31.2149 -19.6487 -27.980627 -33.3946 -45.681143 -41.1565 -42.52629 -30.935704
    Affimetrix absolute value 3.465 3.331 3.374 3.329 3.247 3.201 3.145 3.299
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: sensory organ precursor cell fate determination; compound eye development; dendrite morphogenesis; neuron development; mesoderm development.
80 alleles are reported.
The phenotypes of these alleles are annotated with 30 unique terms, many of which group under: organ system subdivision; adult segment; adult mesothoracic segment; nervous system; external compound sense organ; peripheral nervous system; sensillum; somatic stem cell; epithelial furrow; external sensory organ precursor cell; gustatory sensory organ; late extended germ band embryo.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Helix-loop-helix DNA-binding; Helix-loop-helix DNA-binding domain; Orange; Orange subgroup.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of no expression detected.
Peak expression observed within 06-12 hour embryonic stages.
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