Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name fz
Flybase description The gene frizzled is referred to in FlyBase by the symbol Dmel\fz (CG17697, FBgn0001085).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.207 -8.4051 -26.919201 -25.2105 -39.98426 -3.943 -20.11107 -16.532674
    Affimetrix absolute value 6.129 4.625 3.432 3.767 3.442 6.586 4.27 4.239
    Affymetric present call in "x" number of chips 2 0 0 0 0 3 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: Wnt receptor activity.
There is experimental evidence for 20 unique biological process terms, many of which group under: anatomical structure development; cellular component organization or biogenesis; biological regulation; sensory organ development; establishment of planar polarity; post-embryonic appendage morphogenesis; regulation of biological process; epithelial cell differentiation; cellular process involved in reproduction; cell division; ommatidial rotation; gland morphogenesis.
182 alleles are reported.
The phenotypes of these alleles are annotated with 37 unique terms, many of which group under: organ system subdivision; adult segment; external compound sense organ; adult mesothoracic segment; peripheral nervous system; female germline cyst; appendage segment; integumentary specialisation; non-connected developing system; somatic stem cell; embryonic/larval neuron; wing hair; dorsal thoracic disc; organelle; adult cuticle; external sensory organ precursor cell; embryonic foregut.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Frizzled domain; Frizzled protein; Frizzled-related; GPCR, family 2-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 00-18 hour embryonic stages.
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