Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name h
Flybase description The gene hairy is referred to in FlyBase by the symbol Dmel\h (CG6494, FBgn0001168).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 7.8333 15.5564 6.107344 6.6288 3.615096 5.9858 9.12236 6.626663
    Affimetrix absolute value 11.368 11.572 10.748 11.05 10.57 11.115 11.704 10.893
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II core promoter proximal region sequence-specific DNA binding; protein binding; E-box binding.
There is experimental evidence that it is involved in the biological process: response to hypoxia; tube morphogenesis; regulation of cellular metabolic process; negative regulation of transcription from RNA polymerase II promoter; cell morphogenesis; open tracheal system development; negative regulation of transcription, DNA-dependent; salivary gland morphogenesis.
200 alleles are reported.
The phenotypes of these alleles are annotated with 51 unique terms, many of which group under: adult segment; abdominal ventral denticle belt; organ system subdivision; larval abdominal segment; organ system; adult mesothoracic segment; larval abdominal segment 8; somatic cell; prothoracic segment; larval abdominal segment 5.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Helix-loop-helix DNA-binding; Helix-loop-helix DNA-binding domain; Orange; Orange subgroup.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-06 and 18-24 hour embryonic stages.
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