Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name eIF-4a
Flybase description The gene Eukaryotic initiation factor 4a is referred to in FlyBase by the symbol Dmel\eIF-4a (CG9075, FBgn0001942).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 10.4407 18.4098 11.794716 8.9574 6.360428 7.568 8.95877 9.797004
    Affimetrix absolute value 11.788 11.799 11.73 11.543 11.425 11.476 11.693 11.484
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity; RNA helicase activity.
There is experimental evidence that it is involved in the biological process: germ-line stem cell maintenance; mitotic spindle elongation; response to DNA damage stimulus; mitosis; mitotic spindle organization; dorsal/ventral axis specification; oogenesis; female germ-line stem cell division; regulation of alternative nuclear mRNA splicing, via spliceosome.
67 alleles are reported.
The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: multicellular structure; anatomical structure; organ system; cuticle; organ system subdivision; parasegment 9; dorsal thoracic disc; parasegment 14; parasegment 2; cephalopharyngeal skeleton; external compound sense organ; late extended germ band embryo.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: DEAD-like helicase; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; RNA helicase, ATP-dependent, DEAD-box, conserved site; RNA helicase, DEAD-box type, Q motif.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression.
Peak expression observed within 00-18 hour embryonic stages.
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