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Gene name | nec | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene necrotic is referred to in FlyBase by the symbol Dmel\nec (CG1857, FBgn0002930). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: serine-type endopeptidase inhibitor activity. There is experimental evidence that it is involved in the biological process: immune response; negative regulation of Toll signaling pathway; antifungal humoral response; regulation of proteolysis. 35 alleles are reported. The phenotypes of these alleles are annotated with: adult epidermis; adult cuticle; adult integumentary system; adult abdomen; joint. It has one annotated transcript and one annotated polypeptide. Protein features are: Protease inhibitor I4, serpin; Protease inhibitor I4, serpin, conserved site; Serpin domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed at stages throughout the pupal period, in stages of adults of both sexes. . |