Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name run
Flybase description The gene runt is referred to in FlyBase by the symbol Dmel\run (CG1849, FBgn0003300).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -52.4143 -39.0581 -52.104006 -60.8737 -82.321045 -73.073 -61.78741 -54.997245
    Affimetrix absolute value 2.697 2.343 2.512 2.467 2.413 2.385 2.613 2.495
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; axon guidance; dendrite morphogenesis; germ-band extension; eye morphogenesis; positive regulation of transcription, DNA-dependent.
100 alleles are reported.
The phenotypes of these alleles are annotated with 29 unique terms, many of which group under: organ system subdivision; organ system; external compound sense organ; nervous system; cuticle; thoracic segment; embryonic segment; abdominal ventral denticle belt; extended germ band embryo; abdominal segment 7; gland; abdominal segment 8; abdominal segment 10; embryonic/larval neuron; cephalopharyngeal skeleton.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Acute myeloid leukemia 1 (AML 1)/Runt; Acute myeloid leukemia 1 protein (AML 1)/Runt; p53-like transcription factor, DNA-binding; p53/RUNT-type transcription factor, DNA-binding domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression.
Peak expression observed within 00-12 hour embryonic stages.
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