Flygut: an atlas of the Drosophila adult midgut

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Gene name smo
Flybase description The gene smoothened is referred to in FlyBase by the symbol Dmel\smo (CG11561, FBgn0003444).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.3332 -5.47 -13.588413 -8.053 -17.271387 -10.9731 -8.12383 -13.295122
    Affimetrix absolute value 6.3 5.173 4.496 5.392 4.694 5.114 5.545 4.58
    Affymetric present call in "x" number of chips 3 3 3 3 2 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: blastoderm segmentation; smoothened signaling pathway; eye-antennal disc morphogenesis; ovarian follicle cell development; somatic stem cell maintenance; regulation of mitotic cell cycle; negative regulation of S phase of mitotic cell cycle; eye morphogenesis; Bolwig's organ morphogenesis.
203 alleles are reported.
The phenotypes of these alleles are annotated with 35 unique terms, many of which group under: adult segment; organ system subdivision; organ system; abdominal ventral denticle belt; adult mesothoracic segment; larval abdominal segment; primordium; nervous system; embryonic/larval tracheal system; multi-cell-component structure.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Frizzled domain; Frizzled protein; Frizzled-related; GPCR, family 2-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages.
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