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Gene name | tld | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene tolloid is referred to in FlyBase by the symbol Dmel\tld (CG6868, FBgn0003719). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: metalloendopeptidase activity. There is experimental evidence that it is involved in the biological process: torso signaling pathway; terminal region determination; imaginal disc-derived wing vein morphogenesis; maternal specification of dorsal/ventral axis, oocyte, soma encoded; protein maturation by peptide bond cleavage. 94 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; organ system subdivision; adult segment; portion of tissue; extended germ band embryo; adult mesothoracic segment; nervous system; non-connected developing system; organelle; primordium; epithelial furrow; external compound sense organ; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. Protein features are: Bone morphogenetic protein 1/tolloid-like protein; CUB; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like, type 3; Metallopeptidase, catalytic domain; Peptidase M12A, astacin; Peptidase, metallopeptidase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. . |