Flygut: an atlas of the Drosophila adult midgut

 Mouche Logo lab lemaitre Bbcf logo
Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Egfr
Flybase description The gene Epidermal growth factor receptor is referred to in FlyBase by the symbol Dmel\Egfr (CG10079, FBgn0003731).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.7491 -3.6795 -11.494165 -13.2497 -13.560225 -8.4991 -4.17364 -11.478498
    Affimetrix absolute value 6.179 5.753 4.68 4.707 5.017 5.506 6.523 4.833
    Affymetric present call in "x" number of chips 3 3 1 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: epidermal growth factor receptor activity.
There is experimental evidence for 46 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular process involved in reproduction; organ development; sensory organ development; post-embryonic organ morphogenesis; cellular component organization or biogenesis; regulation of developmental process; multicellular organismal reproductive process; post-embryonic appendage morphogenesis; embryonic pattern specification; embryonic development via the syncytial blastoderm.
161 alleles are reported.
The phenotypes of these alleles are annotated with 228 unique terms, many of which group under: organ system subdivision; adult segment; larval abdominal segment; primordium; external compound sense organ; hypodermal muscle of larval abdomen; imaginal precursor; larval abdominal segment 5; ventral nerve cord primordium; abdominal ventral denticle belt.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: 14-3-3 domain; 14-3-3 protein; 14-3-3 protein, conserved site; EGF receptor, L domain; Furin-like cysteine-rich domain; Furin-like repeat; Growth factor, receptor; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-12 hour embryonic stages, during early pupal stages.
.