Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name ptc
Flybase description The gene patched is referred to in FlyBase by the symbol Dmel\ptc (CG2411, FBgn0003892).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -20.1375 -7.8699 -15.053521 -16.9608 -26.179209 -21.224 -20.69083 -17.367064
    Affimetrix absolute value 4.101 4.646 4.311 4.305 4.062 4.155 4.186 4.266
    Affymetric present call in "x" number of chips 0 3 1 0 2 2 1 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; hedgehog receptor activity; lipoprotein particle receptor activity.
There is experimental evidence for 12 unique biological process terms, many of which group under: anatomical structure development; biological regulation; regulation of biological process; organ development; organ morphogenesis; post-embryonic organ morphogenesis; cellular component organization or biogenesis; multicellular organismal reproductive process; post-embryonic appendage morphogenesis; chemical homeostasis; regulation of response to stimulus; regulation of protein transport; sensory organ development; determination of imaginal disc primordium; multicellular organism reproduction.
179 alleles are reported.
The phenotypes of these alleles are annotated with 86 unique terms, many of which group under: organ system subdivision; adult segment; adult mesothoracic segment; abdominal ventral denticle belt; organ system; nervous system; imaginal precursor; presumptive embryonic/larval nervous system; embryonic/larval neuron; commissure.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Patched; Sterol-sensing domain; Transmembrane receptor, patched.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed within 00-12 hour embryonic stages.
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