Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name kst
Flybase description The gene karst is referred to in FlyBase by the symbol Dmel\kst (CG12008, FBgn0004167).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.6295 2.299 0.557911 2.3505 -1.811262 1.3452 -0.41385 -0.938009
    Affimetrix absolute value 6.2 8.807 8.418 9.603 7.992 8.976 8.453 7.742
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: actin binding; microtubule binding.
There is experimental evidence that it is involved in the biological process: endocytosis; cytokinesis.
23 alleles are reported.
The phenotypes of these alleles are annotated with 13 unique terms, many of which group under: organ system; female germline cyst; organ system subdivision; external compound sense organ; peripheral nervous system; nervous system; adult tracheal system; adult segment; gut section; compound cell cluster organ; gamete; adult mesothoracic segment.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: Actinin-type, actin-binding, conserved site; Calponin homology domain; Pleckstrin homology domain; Pleckstrin homology-type; Spectrin repeat; Spectrin/alpha-actinin; Spectrin/pleckstrin-like; Src homology-3 domain; Variant SH3.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 12-24 hour embryonic stages, during late pupal stages.
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