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Gene name | 5-HT1A | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene Serotonin receptor 1A is referred to in FlyBase by the symbol Dmel\5-HT1A (CG16720, FBgn0004168). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: G-protein coupled amine receptor activity; serotonin receptor activity. There is experimental evidence that it is involved in the biological process: regulation of circadian sleep/wake cycle, sleep; activation of phospholipase C activity by serotonin receptor signaling pathway; inhibition of adenylate cyclase activity by serotonin receptor signaling pathway; anesthesia-resistant memory. 11 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: GPCR, rhodopsin-like superfamily; GPCR, rhodopsin-like, 7TM. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages. . |