Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Ser
Flybase description The gene Serrate is referred to in FlyBase by the symbol Dmel\Ser (CG6127, FBgn0004197).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -52.9527 -9.993 -53.928284 -52.4416 -61.165526 -35.6471 -6.66882 -45.184507
    Affimetrix absolute value 2.693 4.334 2.429 2.747 2.862 3.441 5.828 2.802
    Affymetric present call in "x" number of chips 0 3 0 2 0 3 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: Notch binding; protein binding.
There is experimental evidence for 15 unique biological process terms, many of which group under: anatomical structure development; biological regulation; organ development; gland morphogenesis; leg morphogenesis; sensory organ development; hemocyte differentiation; leg segmentation; cell-cell signaling; signaling; regulation of biological process.
80 alleles are reported.
The phenotypes of these alleles are annotated with 62 unique terms, many of which group under: adult segment; organ system subdivision; external compound sense organ; adult mesothoracic segment; cephalopharyngeal skeleton; appendage segment; spiracle; gland; peripheral nervous system; nervous system.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Delta/Serrate/lag-2 (DSL) protein; EGF; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like; Epidermal growth factor-like, type 3; Notch ligand, N-terminal; VWC out.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression.
Peak expression observed within 06-18 hour embryonic stages, at stages throughout the pupal period.
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