Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name fwd
Flybase description The gene four wheel drive is referred to in FlyBase by the symbol Dmel\fwd (CG7004, FBgn0004373).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.177 -1.3555 -3.248243 -2.2905 -5.615487 -2.2663 0.28068 -3.979437
    Affimetrix absolute value 7.296 7.189 6.525 7.218 6.301 7.388 8.489 6.348
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: 1-phosphatidylinositol 4-kinase activity.
There is experimental evidence that it is involved in the biological process: male meiosis cytokinesis; contractile ring contraction involved in cell cycle cytokinesis; male germline ring canal formation; determination of adult lifespan; meiotic spindle stabilization; cytokinesis after meiosis II; spermatocyte division; spermatogenesis; cytokinesis after meiosis I.
23 alleles are reported.
The phenotypes of these alleles are annotated with: secondary spermatocyte; Nebenkern; Nebenkern derivative; spermatid; spermatid axoneme; spermatozoon.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: Phosphatidylinositol 3-/4-kinase, catalytic; Phosphatidylinositol 3/4-kinase, conserved site; Phosphatidylinositol Kinase; Protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes.
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