Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name sim
Flybase description The gene single-minded is referred to in FlyBase by the symbol Dmel\sim (CG7771, FBgn0004666).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -39.0528 -23.7767 -30.967366 -39.0791 -50.864253 -44.5205 -42.74202 -36.774005
    Affimetrix absolute value 3.137 3.066 3.233 3.102 3.114 3.086 3.141 3.052
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity; RNA polymerase II core promoter proximal region sequence-specific DNA binding; sequence-specific DNA binding.
There is experimental evidence that it is involved in the biological process: adult walking behavior; positive regulation of transcription from RNA polymerase II promoter; axon guidance; determination of genital disc primordium; ventral midline development; brain development; axonogenesis; ventral cord development.
59 alleles are reported.
The phenotypes of these alleles are annotated with 86 unique terms, many of which group under: organ system subdivision; embryonic/larval neuron; VUM1 neuron; adult segment; presumptive embryonic/larval nervous system; VUM2 neuron; peripheral nervous system; primordium; late extended germ band embryo; multi-cell-component structure.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Helix-loop-helix DNA-binding; Helix-loop-helix DNA-binding domain; Nuclear translocator; PAC motif; PAS; PAS fold; PAS fold-3.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression.
Peak expression observed within 00-12 hour embryonic stages, in adult female stages.
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