Flygut: an atlas of the Drosophila adult midgut

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Gene name tok
Flybase description The gene tolkin is referred to in FlyBase by the symbol Dmel\tok (CG6863, FBgn0004885).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -57.7558 -11.4033 -56.072556 -65.0601 -79.148446 -68.0667 -45.38981 -48.947734
    Affimetrix absolute value 2.565 4.186 2.377 2.372 2.452 2.481 3.264 2.669
    Affymetric present call in "x" number of chips 1 3 0 0 0 0 2 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: metalloendopeptidase activity.
There is experimental evidence that it is involved in the biological process: motor axon guidance; axon guidance; defasciculation of motor neuron axon; imaginal disc-derived wing vein morphogenesis; protein maturation by peptide bond cleavage.
36 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system subdivision; adult segment; multi-cell-component structure; presumptive embryonic/larval nervous system; adult mesothoracic segment; peripheral nervous system; organ system; nervous system; hypodermal muscle of larval abdomen; abdominal segmental nerve.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Bone morphogenetic protein 1/tolloid-like protein; CUB; EGF calcium-binding; EGF-like calcium-binding; EGF-like calcium-binding, conserved site; EGF-like region, conserved site; EGF-type aspartate/asparagine hydroxylation site; Epidermal growth factor-like, type 3; Metallopeptidase, catalytic domain; Peptidase M12A, astacin; Peptidase, metallopeptidase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed during late larval stages, during early pupal stages.
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