Flygut: an atlas of the Drosophila adult midgut

 Mouche Logo lab lemaitre Bbcf logo
Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Top1
Flybase description The gene Topoisomerase 1 is referred to in FlyBase by the symbol Dmel\Top1 (CG6146, FBgn0004924).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -5.9321 -1.9041 -2.290574 -2.7516 -3.834754 -3.7592 -3.38774 -3.671432
    Affimetrix absolute value 5.843 6.691 6.997 6.944 6.826 6.658 6.792 6.413
    Affymetric present call in "x" number of chips 0 2 3 3 3 3 2 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: DNA topoisomerase activity; DNA topoisomerase type I activity; protein kinase activity.
There is experimental evidence that it is involved in the biological process: instar larval development; cell proliferation; chromosome segregation; protein phosphorylation; DNA topological change; multicellular organismal development; oogenesis; embryo development; chromosome condensation.
36 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; multicellular structure; female germline cyst; organ system subdivision; germarium; nucleus; egg; sensillum; cell cycle; imaginal precursor; adult segment.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: DNA breaking-rejoining enzyme, catalytic core; DNA topoisomerase I, C-terminal; DNA topoisomerase I, C-terminal, eukaryotic-type; DNA topoisomerase I, DNA binding, eukaryotic-type; DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type; DNA topoisomerase I, active site; DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type; DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type; DNA topoisomerase I, catalytic core, eukaryotic-type; DNA topoisomerase I, domain 1; DNA topoisomerases I, dispensable insert, eukaryotic-type.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-06 hour embryonic stages.
.