Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name ple
Flybase description The gene pale is referred to in FlyBase by the symbol Dmel\ple (CG10118, FBgn0005626).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -48.6572 -15.0892 -43.22102 -43.1819 -52.78445 -56.1203 -56.45868 -41.000241
    Affimetrix absolute value 2.813 3.721 2.757 2.957 3.053 2.752 2.747 2.89
    Affymetric present call in "x" number of chips 0 3 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: tyrosine 3-monooxygenase activity.
There is experimental evidence that it is involved in the biological process: dopamine biosynthetic process; cuticle pigmentation; regulation of epithelial cell migration, open tracheal system; adult locomotory behavior; dopamine metabolic process; thermosensory behavior; thermotaxis; male courtship behavior.
31 alleles are reported.
The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; cuticle; organ system subdivision; adult segment; cephalopharyngeal skeleton; adult mesothoracic segment; adult; integumentary system; acellular anatomical structure; cuticular specialization; thoracic segment; sensillum; adult cuticle; spiracle.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Aromatic amino acid hydroxylase; Aromatic amino acid hydroxylase, C-terminal; Aromatic amino acid hydroxylase, iron/copper binding site; Tyrosine 3-monooxygenase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression.
Peak expression observed at stages throughout the pupal period.
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