Flygut: an atlas of the Drosophila adult midgut

Mouche Logo lab lemaitre Bbcf logo

Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Nmdmc
Flybase description The gene NAD-dependent methylenetetrahydrofolate dehydrogenase is referred to in FlyBase by the symbol Dmel\Nmdmc (CG18466, FBgn0010222).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.8135 -2.1386 -7.943154 -4.5906 -8.543402 -5.6662 2.1286 -3.625065
    Affimetrix absolute value 9.265 6.553 5.208 6.19 5.668 6.066 9.632 6.415
    Affymetric present call in "x" number of chips 3 3 2 3 2 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity; methenyltetrahydrofolate cyclohydrolase activity.
Based on sequence similarity, it is predicted to be involved in the biological process: 10-formyltetrahydrofolate metabolic process; carbohydrate metabolic process.
16 alleles are reported.
No phenotypic data is available.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed during late larval stages, during early pupal stages.
.