Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Sply
Flybase description The gene Sphingosine-1-phosphate lyase is referred to in FlyBase by the symbol Dmel\Sply (CG8946, FBgn0010591).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.3592 1.6217 2.77598 5.2167 4.086963 5.2137 0.46033 3.848769
    Affimetrix absolute value 7.997 8.312 9.495 10.768 10.709 10.906 8.707 10.062
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sphinganine-1-phosphate aldolase activity.
There is experimental evidence that it is involved in the biological process: sphingolipid catabolic process; lateral inhibition.
6 alleles are reported.
The phenotypes of these alleles are annotated with: dorsal medial muscle; chaeta.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Pyridoxal phosphate-dependent decarboxylase; Pyridoxal phosphate-dependent transferase, major domain; Pyridoxal phosphate-dependent transferase, major region, subdomain 1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression.
Peak expression observed during late larval stages, during early pupal stages.
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