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Gene name | msn | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene misshapen is referred to in FlyBase by the symbol Dmel\msn (CG16973, FBgn0010909). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity; MAP kinase kinase kinase kinase activity. There is experimental evidence that it is involved in the biological process: regulation of cell shape; regulation of embryonic cell shape; dorsal closure; axon guidance; optic lobe placode development; JNK cascade; imaginal disc fusion, thorax closure; photoreceptor cell morphogenesis; nuclear migration. 42 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system subdivision; multi-cell-component structure; external compound sense organ; adult segment; peripheral nervous system; nervous system; cell projection; imaginal precursor; rhabdomere; synaptic neuropil subdomain; wing hair; primordium; axon. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Citron-like; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period. . |