Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name fra
Flybase description The gene frazzled is referred to in FlyBase by the symbol Dmel\fra (CG8581, FBgn0011592).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -7.2273 -2.4821 -2.577452 -2.9404 -3.338408 -1.1973 -12.87318 -3.577372
    Affimetrix absolute value 5.568 6.314 6.871 6.863 7.085 8.324 5.079 6.462
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: netrin receptor activity.
There is experimental evidence that it is involved in the biological process: motor axon guidance; salivary gland boundary specification; axon guidance; dendrite morphogenesis; axon midline choice point recognition; dendrite guidance.
37 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system subdivision; nervous system; multi-cell-component structure; embryonic/larval neuron; commissure; peripheral nervous system; presumptive embryonic/larval nervous system; non-connected developing system; cell projection; embryonic foregut.
It has 2 annotated transcripts and 2 annotated polypeptides.
Protein features are: Fibronectin type III domain; Fibronectin, type III; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; Neogenin, C-terminal.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-18 hour embryonic stages.
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