Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name E2f
Flybase description The gene E2F transcription factor is referred to in FlyBase by the symbol Dmel\E2f (CG6376, FBgn0011766).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.6493 0.5151 -1.285619 -1.4811 -2.368119 -2.1072 -1.60363 -1.97098
    Affimetrix absolute value 7.689 7.848 7.817 7.842 7.519 7.492 7.924 7.304
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; DNA binding.
There is experimental evidence that it is involved in the biological process: positive regulation of gene expression; cellular process; dendrite morphogenesis; neuron development; positive regulation of nurse cell apoptosis; muscle tissue development; antimicrobial humoral response; regulation of cell cycle; DNA endoreduplication.
77 alleles are reported.
The phenotypes of these alleles are annotated with 37 unique terms, many of which group under: organ system subdivision; external compound sense organ; primordium; adult segment; organ system; female germline cyst; egg; nervous system; imaginal precursor; adult mesothoracic segment.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: E2F Family; Transcription factor E2F/dimerisation partner (TDP); Winged helix-turn-helix transcription repressor DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages.
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