Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name klu
Flybase description The gene klumpfuss is referred to in FlyBase by the symbol Dmel\klu (CG12296, FBgn0013469).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -33.1513 -10.9128 -15.475783 -25.2005 -31.47876 -19.2844 -20.24039 -26.12402
    Affimetrix absolute value 3.362 4.189 4.297 3.754 3.882 4.31 4.215 3.569
    Affymetric present call in "x" number of chips 0 2 1 0 1 2 0 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: nucleic acid binding.
There is experimental evidence that it is involved in the biological process: larval feeding behavior; tricarboxylic acid cycle; positive regulation of compound eye retinal cell programmed cell death.
31 alleles are reported.
The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: organ system subdivision; adult segment; embryonic/larval neuron; external compound sense organ; peripheral nervous system; appendage segment; antennal segment; adult mesothoracic segment; nervous system; larval abdominal segment 5; abdominal 6 RP2 neuron.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression.
Peak expression observed within 06-18 hour embryonic stages.
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