Flygut: an atlas of the Drosophila adult midgut

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Gene name tim
Flybase description The gene timeless is referred to in FlyBase by the symbol Dmel\tim (CG3234, FBgn0014396).
Expression data along the gut
    Created with Highcharts 6.0.3Fold change compared to full gutRegion-specific expression of tim along the gutCropCardia/R1R2R3R4R5Hindgut-2-10123Highcharts.com
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -12.4326 -2.5459 -3.581345 -3.3802 -7.121754 -6.7519 -8.78728 -7.447587
    Affimetrix absolute value 4.781 6.271 6.352 6.657 5.935 5.843 5.475 5.427
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Created with Highcharts 6.0.3Fold change compared toUnchallengedFold change compared to UnchallengedExpression of tim in different experimental conditionsEcc15 4hEcc15 16hPe 4hPe 16hPe gacA 4hPe gacA 16h-3-2-1012Highcharts.com
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence that it is involved in the biological process: regulation of circadian sleep/wake cycle, sleep; negative phototaxis; circadian behavior; photoperiodism; regulation of circadian sleep/wake cycle; locomotor rhythm; mating behavior; copulation.
70 alleles are reported.
The phenotypes of these alleles are annotated with: indirect flight muscle motor neuron MN5; Malpighian tubule; posterior adult hindgut.
It has 8 annotated transcripts and 8 annotated polypeptides.
Protein features are: Timeless protein.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression.
Peak expression observed in adults stages of both sexes.
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