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Gene name | Iap2 | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene Inhibitor of apoptosis 2 is referred to in FlyBase by the symbol Dmel\Iap2 (CG8293, FBgn0015247). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. There is experimental evidence that it is involved in the biological process: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria; anti-apoptosis; negative regulation of caspase activity; sensory organ development; negative regulation of apoptosis; defense response to Gram-negative bacterium; peptidoglycan recognition protein signaling pathway; regulation of caspase activity; positive regulation of protein import into nucleus, translocation. 31 alleles are reported. The phenotypes of these alleles are annotated with: wing disc; trichogen cell; mesothoracic tergum; pigment cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Baculoviral inhibition of apoptosis protein repeat; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. . |