Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name ksr
Flybase description The gene kinase suppressor of ras is referred to in FlyBase by the symbol Dmel\ksr (CG2899, FBgn0015402).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -23.3291 -15.2223 -20.157633 -20.5833 -35.52164 -27.2034 -18.34637 -29.790371
    Affimetrix absolute value 3.87 3.708 3.846 4.045 3.672 3.819 4.424 3.386
    Affymetric present call in "x" number of chips 3 3 1 3 1 3 3 2
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein kinase activity; diacylglycerol binding; protein serine/threonine kinase activity.
There is experimental evidence that it is involved in the biological process: Ras protein signal transduction; tracheal outgrowth, open tracheal system; imaginal disc-derived wing morphogenesis; signal transduction.
45 alleles are reported.
The phenotypes of these alleles are annotated with: eye; photoreceptor cell; mesothoracic tergum; eye photoreceptor cell; wing; ommatidium.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protein kinase C-like, phorbol ester/diacylglycerol binding; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression.
Peak expression observed within 00-18 hour embryonic stages, in adult female stages.
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