Flygut: an atlas of the Drosophila adult midgut

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Gene name Lis-1
Flybase description The gene Lissencephaly-1 is referred to in FlyBase by the symbol Dmel\Lis-1 (CG8440, FBgn0015754).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -3.2273 -2.9508 -6.002179 -6.977 -8.366668 -5.9008 -4.18518 -6.300188
    Affimetrix absolute value 6.785 6.094 5.599 5.608 5.699 6.001 6.496 5.624
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled; dynein binding; enzyme regulator activity.
There is experimental evidence for 25 unique biological process terms, many of which group under: localization; cellular component organization or biogenesis; multicellular organism reproduction; biological regulation; cellular localization; germarium-derived oocyte differentiation; gamete generation; cell proliferation; cellular macromolecule localization; microtubule-based movement; cell cycle; cell fate commitment.
28 alleles are reported.
The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: organ system; multicellular structure; anatomical structure; organelle; cytoplasmic part; intracellular organelle part; spindle; extended germ band embryo; acellular anatomical structure; intracellular non-membrane-bounded organelle.
It has 7 annotated transcripts and 7 annotated polypeptides.
Protein features are: Dynein regulator; G-protein beta WD-40 repeat; LisH dimerisation motif; LisH dimerisation motif, subgroup; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages.
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