Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name nrv2
Flybase description The gene nervana 2 is referred to in FlyBase by the symbol Dmel\nrv2 (CG9261, FBgn0015777).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -1.6192 -8.195 -25.012927 -35.4946 -41.235005 -30.9466 -11.74231 -18.726409
    Affimetrix absolute value 7.723 4.627 3.538 3.263 3.405 3.627 5.024 4.045
    Affymetric present call in "x" number of chips 3 3 0 0 1 2 3 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: sodium:potassium-exchanging ATPase activity; cation transmembrane transporter activity.
There is experimental evidence that it is involved in the biological process: regulation of tube diameter, open tracheal system; regulation of tube size, open tracheal system; establishment of glial blood-brain barrier; open tracheal system development; regulation of tube length, open tracheal system; cation transport; septate junction assembly.
25 alleles are reported.
The phenotypes of these alleles are annotated with: tracheal branch primordium; presumptive embryonic salivary gland; trichogen cell; embryonic somatic muscle; embryonic/larval dorsal trunk; septate junction; embryonic/larval tracheal system; dorsal trunk primordium; embryonic/larval transverse connective; ganglionic branch primordium.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: ATPase, P-type cation exchange, beta subunit.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression.
Peak expression observed within 06-24 hour embryonic stages, during early larval stages, at stages throughout the pupal period, in adult male stages.
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