Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name fz2
Flybase description The gene frizzled 2 is referred to in FlyBase by the symbol Dmel\fz2 (CG9739, FBgn0016797).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -41.0865 -21.9156 -32.700026 -31.9696 -45.306963 -43.1594 -47.20832 -33.98798
    Affimetrix absolute value 3.055 3.169 3.154 3.404 3.262 3.13 3.01 3.178
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 1
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: Wnt receptor activity; PDZ domain binding; Wnt-protein binding.
There is experimental evidence that it is involved in the biological process: female gonad development; cellular component movement; imaginal disc-derived wing margin morphogenesis; receptor-mediated endocytosis; retinal ganglion cell axon guidance; bristle morphogenesis; Wnt receptor signaling pathway; axon extension; salivary gland morphogenesis; synapse organization.
117 alleles are reported.
The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system; organ system subdivision; adult segment; external compound sense organ; peripheral nervous system; synapse; acellular anatomical structure; thoracic segment; embryonic/larval neuron; postsynaptic membrane; embryonic foregut.
It has 4 annotated transcripts and 4 annotated polypeptides.
Protein features are: Frizzled domain; Frizzled protein; Frizzled-related; GPCR, family 2-like.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-18 hour embryonic stages, during early pupal stages.
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