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Gene name | lok | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene loki is referred to in FlyBase by the symbol Dmel\lok (CG10895, FBgn0019686). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein kinase activity; protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: apoptosis; activation of caspase activity; germ cell programmed cell death; response to DNA damage stimulus; germ cell development; DNA damage response, signal transduction resulting in induction of apoptosis; DNA damage checkpoint. 14 alleles are reported. The phenotype of these alleles is annotated with: egg chamber. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Forkhead-associated (FHA) domain; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; SMAD/FHA domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. . |