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Gene name | Ice | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene Ice is referred to in FlyBase by the symbol Dmel\Ice (CG7788, FBgn0019972). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: salivary gland histolysis; spermatid differentiation; programmed cell death; sterol regulatory element binding protein cleavage; neuron remodeling; positive regulation of compound eye retinal cell programmed cell death; response to X-ray; developmental programmed cell death. 29 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: organ system; organ system subdivision; adult; multicellular structure; external compound sense organ; adult segment; region of integument; cell part; imaginal precursor; multi-tissue structure; anatomical structure; cell projection. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase C14, ICE, catalytic subunit p20; Peptidase C14, ICE, catalytic subunit p20, active site; Peptidase C14, caspase catalytic; Peptidase C14, caspase non-catalytic subunit p10; Peptidase C14, caspase precursor p45; Peptidase C14, caspase precursor p45, core. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, during early pupal stages. . |