Flygut: an atlas of the Drosophila adult midgut

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Gene name Pk61C
Flybase description The gene Phosphoinositide-dependent kinase 1 is referred to in FlyBase by the symbol Dmel\Pdk1 (CG1210, FBgn0020386).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 0.2998 2.4023 3.41968 1.4118 0.357973 1.1818 -0.47932 1.195984
    Affimetrix absolute value 8.369 8.847 9.896 8.865 8.792 8.799 8.37 9.011
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity.
There is experimental evidence that it is involved in the biological process: anti-apoptosis; regulation of organ growth; positive regulation of cell size; response to DNA damage stimulus; regulation of cell growth; protein phosphorylation; cell surface receptor linked signaling pathway.
66 alleles are reported.
The phenotypes of these alleles are annotated with: eye; embryonic ventral epidermis; macrochaeta; adult head; intersegmental nerve; wing; ommatidium.
It has 9 annotated transcripts and 9 annotated polypeptides.
Protein features are: Pleckstrin homology-type; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase-like domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis.
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