Flygut: an atlas of the Drosophila adult midgut

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Gene name Trxr-1
Flybase description The gene Thioredoxin reductase-1 is referred to in FlyBase by the symbol Dmel\Trxr-1 (CG2151, FBgn0020653).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 2.2414 8.1216 7.000988 2.164 3.673838 4.3359 2.09375 4.778955
    Affimetrix absolute value 9.563 10.635 10.968 9.497 10.626 10.661 9.604 10.458
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: glutathione-disulfide reductase activity; thioredoxin-disulfide reductase activity; antioxidant activity; protein homodimerization activity.
There is experimental evidence that it is involved in the biological process: response to hypoxia; determination of adult lifespan; response to DNA damage stimulus; neurogenesis.
24 alleles are reported.
No phenotypic data is available.
It has 3 annotated transcripts and 3 annotated polypeptides.
Protein features are: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; FAD/NAD-linked reductase, dimerisation; Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain; Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain; Pyridine nucleotide-disulphide oxidoreductase, class I, active site; Pyridine nucleotide-disulphide oxidoreductase, dimerisation; Thioredoxin/glutathione reductase selenoprotein.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression.
Peak expression observed within 00-06 and 18-24 hour embryonic stages, during early larval stages, in stages of adults of both sexes.
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