Flygut: an atlas of the Drosophila adult midgut

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Gene name Nle
Flybase description The gene Notchless is referred to in FlyBase by the symbol Dmel\Nle (CG2863, FBgn0021874).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.3724 -3.4127 -4.028331 -5.0034 -5.1796 -6.1905 -5.69968 -5.115818
    Affimetrix absolute value 6.283 5.852 6.173 6.08 6.402 5.97 6.069 5.901
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
It is reported to have molecular function: Notch binding.
Based on sequence similarity, it is predicted to be involved in the biological process: Notch signaling pathway.
8 alleles are reported.
The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum; microchaeta.
It has one annotated transcript and one annotated polypeptide.
Protein features are: G-protein beta WD-40 repeat; G-protein, beta subunit; NLE; Quinonprotein alcohol dehydrogenase-like; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed during early larval stages.
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