Flygut: an atlas of the Drosophila adult midgut

 Mouche Logo lab lemaitre Bbcf logo
Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
Search expression data by gene:
Gene name Uba1
Flybase description The gene Ubiquitin activating enzyme 1 is referred to in FlyBase by the symbol Dmel\Uba1 (CG1782, FBgn0023143).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 1.2064 2.767 1.772181 1.7274 0.435347 1.5446 1.86286 1.442613
    Affimetrix absolute value 8.675 9.071 8.995 9.161 8.885 9.154 9.422 8.728
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: ubiquitin activating enzyme activity.
There is experimental evidence that it is involved in the biological process: regulation of Ras protein signal transduction; cell proliferation; neuron remodeling; mushroom body development; lipid storage; protein ubiquitination.
42 alleles are reported.
The phenotypes of these alleles are annotated with: leg; proboscis; macrochaeta; humeral disc; intersegmental nerve; eye disc posterior to the morphogenetic furrow.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Molybdenum cofactor biosynthesis, MoeB; NAD(P)-binding domain; UBA/THIF-type NAD/FAD binding fold; Ubiquitin-activating enzyme; Ubiquitin-activating enzyme e1, C-terminal; Ubiquitin-activating enzyme repeat; Ubiquitin-activating enzyme, E1; Ubiquitin-activating enzyme, E1, active site; Ubiquitin-like 1 activating enzyme, catalytic cysteine domain; Ubiquitin/SUMO-activating enzyme E1.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression.
Peak expression observed within 00-06 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages.
.