Flygut: an atlas of the Drosophila adult midgut

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Gene name Sir2
Flybase description The gene Sir2 is referred to in FlyBase by the symbol Dmel\Sir2 (CG5216, FBgn0024291).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -0.3696 1.4767 -1.679795 -1.376 -2.79065 -1.5785 0.33248 -2.091285
    Affimetrix absolute value 8.358 8.162 7.488 7.931 7.335 7.905 8.552 7.342
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: NAD-dependent histone deacetylase activity; histone deacetylase activity.
There is experimental evidence that it is involved in the biological process: regulation of apoptosis; histone deacetylation; regulation of transcription, DNA-dependent; determination of adult lifespan; regulation of histone acetylation; behavioral response to ethanol; chromatin silencing; response to nutrient.
28 alleles are reported.
The phenotypes of these alleles are annotated with: nucleolus; chromatin.
It has one annotated transcript and one annotated polypeptide.
Protein features are: NAD-dependent histone deacetylase, silent information regulator Sir2.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-12 hour embryonic stages.
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