Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Crk
Flybase description The gene Crk is referred to in FlyBase by the symbol Dmel\Crk (CG1587, FBgn0024811).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 5.1312 3.43 2.069043 2.581 1.600849 1.7162 2.26472 2.14547
    Affimetrix absolute value 10.758 9.386 9.222 9.752 9.434 9.339 9.714 9.316
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding; SH3/SH2 adaptor activity.
There is experimental evidence that it is involved in the biological process: imaginal disc fusion, thorax closure; positive regulation of JNK cascade.
10 alleles are reported.
The phenotype of these alleles is annotated with: thorax.
It has 5 annotated transcripts and 5 annotated polypeptides.
Protein features are: SH2 motif; Src homology-3 domain; Variant SH3.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed within 00-18 hour embryonic stages.
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