Flygut: an atlas of the Drosophila adult midgut

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Gene name Irp-1A
Flybase description The gene Iron regulatory protein 1A is referred to in FlyBase by the symbol Dmel\Irp-1A (CG4900, FBgn0024958).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.6314 -1.4149 -1.675471 -1.5456 -2.111035 -2.351 -2.44489 -1.766413
    Affimetrix absolute value 7.028 7.136 7.453 7.778 7.701 7.352 7.286 7.423
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: iron-responsive element binding; aconitate hydratase activity.
Based on sequence similarity, it is predicted to be involved in the biological process: regulation of translational initiation by iron.
3 alleles are reported.
No phenotypic data is available.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Aconitase A/isopropylmalate dehydratase small subunit, swivel; Aconitase family, 4Fe-4S cluster binding site; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2; Aconitase/3-isopropylmalate dehydratase, swivel; Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase; Aconitase/iron regulatory protein 2; Aconitase/isopropylmalate dehydratase.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression.
Peak expression observed during late larval stages, during early pupal stages.
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