Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Smox
Flybase description The gene Smad on X is referred to in FlyBase by the symbol Dmel\Smox (CG2262, FBgn0025800).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -4.8932 -3.5011 -5.795981 -3.9634 -9.299953 -4.2641 -2.96238 -8.427147
    Affimetrix absolute value 6.147 5.826 5.668 6.402 5.595 6.479 7.01 5.252
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
Based on sequence similarity, it is predicted to have molecular function: transforming growth factor beta receptor, cytoplasmic mediator activity.
There is experimental evidence that it is involved in the biological process: axon guidance; neuron development; regulation of mitotic cell cycle; mushroom body development; imaginal disc-derived wing morphogenesis.
16 alleles are reported.
The phenotypes of these alleles are annotated with: medulla neuropil; lamina anlage glial cell; medulla neuropil glial cell; larval inner optic anlage; larval outer optic anlage; chaeta; wing; lamina.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Dwarfin; MAD homology 1, Dwarfin-type; MAD homology, MH1; SMAD domain, Dwarfin-type; SMAD domain-like; SMAD/FHA domain.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes.
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