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Gene name | Fen1 | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene Flap endonuclease 1 is referred to in FlyBase by the symbol Dmel\Fen1 (CG8648, FBgn0025832). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endonuclease activity; flap endonuclease activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 3 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: 5'-3' exonuclease, C-terminal subdomain; DNA repair protein (XPGC)/yeast Rad; Flap structure-specific endonuclease; Helix-hairpin-helix DNA-binding motif, class 1; Helix-hairpin-helix motif, class 2; XPG N-terminal; XPG conserved site; XPG/RAD2 endonuclease. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. . |