Flygut: an atlas of the Drosophila adult midgut

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Gene name Tak1
Flybase description The gene TGF-β activated kinase 1 is referred to in FlyBase by the symbol Dmel\Tak1 (CG18492, FBgn0026323).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -2.409 -1.4695 -1.886425 -2.2291 -3.009232 -2.1145 -2.79055 -2.467968
    Affimetrix absolute value 7.145 7.066 7.272 7.243 7.175 7.486 7.083 6.986
    Affymetric present call in "x" number of chips 3 3 3 3 3 3 3 3
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: JUN kinase kinase kinase activity.
There is experimental evidence for 13 unique biological process terms, many of which group under: biological regulation; immune system process; sensory organ development; system development; cellular response to molecule of bacterial origin; immune response; programmed cell death; ommatidial rotation; post-embryonic organ morphogenesis; defense response to bacterium; embryonic development via the syncytial blastoderm.
29 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; external compound sense organ; organ system subdivision; peripheral nervous system; acellular anatomical structure; imaginal precursor; cephalopharyngeal skeleton; proteinaceous extracellular matrix; extracellular matrix part; adult segment.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Serine/threonine-protein kinase, active site.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression.
Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages.
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