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Gene name | Pten | ||||||||||||||||||||||||||||||||||||
Flybase description | The gene Pten is referred to in FlyBase by the symbol Dmel\Pten (CG5671, FBgn0026379). | ||||||||||||||||||||||||||||||||||||
Expression data along the gut |
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Intestinal gene expression in different physiological conditions |
Ecc15: flies orally infected with Erwinia carotovora carotovora 15. Pe: flies orally infected with Pseudomonas entomophila. Pe gacA: flies orally infecte with Pseudomonas entomophila gacA. For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe. |
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Gene details (from Flybase) | It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphoprotein phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; protein serine/threonine phosphatase activity. There is experimental evidence for 26 unique biological process terms, many of which group under: biological regulation; cellular component organization or biogenesis; organelle organization; actin filament-based process; regulation of developmental process; cellular process; cell proliferation; macromolecule modification; programmed cell death; localization; response to nutrient levels; gland morphogenesis; open tracheal system development; catabolic process; metamorphosis. 39 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: organ system; organ system subdivision; external compound sense organ; adult segment; peripheral nervous system; thoracic segment; imaginal precursor; embryonic/larval corpus allatum; embryonic/larval fat body; cell part; cell cycle. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN; C2 calcium/lipid-binding domain, CaLB; Dual specificity phosphatase, catalytic domain; Phosphatase tensin type; Protein-tyrosine phosphatase, active site; Tensin phosphatase, C2 domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in adult female stages. . |