Flygut: an atlas of the Drosophila adult midgut

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Home Overview of gut regions Anatomy Histology Transgene expression mapping Gene expression
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Gene name Apc2
Flybase description The gene Adenomatous polyposis coli tumor suppressor homolog 2 is referred to in FlyBase by the symbol Dmel\Apc2 (CG6193, FBgn0026598).
Expression data along the gut
    Crop Cardia/R1 R2 R3 R4 R5 Hindgut Full gut
    Ratio gene/RPL42 -45.986 -28.6784 -41.34006 -49.1764 -52.170344 -55.0747 -67.22746 -47.895752
    Affimetrix absolute value 2.893 2.785 2.823 2.78 3.066 2.781 2.504 2.693
    Affymetric present call in "x" number of chips 0 0 0 0 0 0 0 0
Intestinal gene expression in different physiological conditions
Ecc15: flies orally infected with Erwinia carotovora carotovora 15.
Pe: flies orally infected with Pseudomonas entomophila.
Pe gacA: flies orally infecte with Pseudomonas entomophila gacA.
For methods and description, see Buchon et al. 2009, Cell Host Microbe, and Chakrabarti et al. 2012, Cell Host Microbe.
Gene details (from Flybase) It is a protein_coding_gene from Drosophila melanogaster.
There is experimental evidence that it has the molecular function: protein binding.
There is experimental evidence for 16 unique biological process terms, many of which group under: system development; multicellular organismal development; embryonic development via the syncytial blastoderm; cellular process; cellular component organization or biogenesis; localization; biological regulation; embryo development ending in birth or egg hatching; cell adhesion; chitin-based cuticle development; regulation of Wnt receptor signaling pathway.
28 alleles are reported.
The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; multicellular structure; non-connected developing system; portion of tissue; late extended germ band embryo; acellular anatomical structure; organ system subdivision; anatomical structure; extended germ band embryo; ovariole; cell part; adherens junction; embryonic/larval integumentary system; external compound sense organ; adult segment.
It has one annotated transcript and one annotated polypeptide.
Protein features are: Adenomatous polyposis coli protein, 15 residue repeat; Adenomatous polyposis coli protein, cysteine-rich repeat; Armadillo; Armadillo-like helical; Armadillo-type fold.
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression.
Peak expression observed within 00-06 hour embryonic stages.
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